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Search term: guangdong
Alternate spelling: quandong, guakngdongi
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- Guangdong is a cultured dmem dulbecco modi ed eagle medium hyclone
- Guangdong is a lead death 2019 piglet
- Guangdong is a yunnan
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Guangdong Province China (e.g., caused deadly outbreak respiratory disease -> Corona: In 2003, a novel CoV emerged in the Guangdong Province of China that caused a new and deadly outbreak of respiratory disease in humans termed as severe acute respiratory syndrome (SARS-CoV).).
Mainland China (e.g., collected guangdong institute applied biological resource guangzhou -> Corona: Bat samples from mainland China were collected by the Guangdong Institute of Applied Biological Resources (Guangzhou, China) in accordance with guidelines of Regulations for Administration of Laboratory Animals under a license from Guangdong Entomological Institute Administrative Panel on Laboratory Animal Care. 2.2.).
Enteric Cov (e.g., detection guangdong -> Corona: Discussion Since the ?rst report of PEAV in pigs in early February of 2017 in Guangdong, China (Gong et al., 2017), this novel swine enteric CoV has been widely detected in Guangdong, China, with a prevalence of 43.53% and an emergence in China as early as August 2016 by a retrospective detection study (Zhou et al., 2019).).
Virus (e.g., emerged guangdong -> Corona: A retrospective study indicated that the virus had emerged in Guangdong since 53 August 2016 (Zhou et al., 2019).).
Sar Rst (e.g., emerged guangdong province -> Corona: The emergence and tracing the animal origin of SARS In late 2002, SARS ?rst emerged in Guangdong Province in southern China, and rapidly spread to other provinces and other countries, resulting in a global pandemic of severe respiratory diseases (Zhong et al., 2003).).
Sar Cov (e.g., emerged guangdong province southeasternchina -> Corona: Air travel facilitated these CoVs in seeding outbreaks in regions distant from initial localized viral spread: SARS-CoV emerged in the Guangdong province of southeasternChina in late 2002, and then spread rapidly to other parts of the world, with outbreaks in major cities including Beijing, Hong Kong, Singapore, and Toronto, resulting in one of the first pandemics of the twenty-first century [5].).
Reported Cov Positive Sample (e.g., find guangdong -> Corona: However, the reported CoV positive samples can only be found in Guangdong, Hong Kong, and Macau, possibly due to a lack of investigation in other provinces.).
Association (e.g., negative guangdong resident -> Corona: Slaughtering poultry was positively associated with the outcome only in Guangxi residents, whereas the association was negative in Guangdong residents.).
Shrew (e.g., obtained region guangdong province china -> Corona: Detection of CoVs in Animals and Discovery of a Novel Species of Merbecovirus from Amur Hedgehogs A total number of 207 alimentary samples, 27 from hedgehogs, 151 from rodents and 29 from shrews were obtained from various regions of the Guangdong province of China and Hong Kong.).
Sar Case (e.g., occur guangdong province -> Corona: Furthermore, there are still unanswered questions about SARS, e.g., Why did the first SARS case occur in Guangdong Province, but all the human-ACE2-using SARSr-CoVs were found in Yunnan Province? and Why does R. sinicus in certain areas carry human-ACE2-using SARSr-CoVs but no Figure 2.).
Sar Epidemic (e.g., originated guangdong province -> Corona: In 2002, a SARS epidemic that originated in Guangdong Province in China resulted in 916 deaths among more than 8098 patients in 29 countries [11], identifying SARS as the first new infectious disease of the 21st century.).
Sar Pandemic (e.g., originated guangdong province -> Corona: The SARS pandemic originated in Guangdong Province in China between 2002 and 2003, and spread to 29 countries, resulting in nearly 8,000 cases and 800 deaths worldwide (Donnelly et al., 2004).).
Duroc Landrace Native Pig Guangdong China (e.g., procured wen -> Corona: Pigs Four-day-old crossbred conventional newborn piglets produced by Duroc Landrace Native pigs of Guangdong of China were procured from Wen' s Foodstu?s Group Co, Ltd (Guangdong, China).).
Guangdong Wildlife Rescue Center (e.g., received 21 live malayan pangolin -> Corona: The Guangdong Wildlife Rescue Center received 21 live Malayan pangolins from the Anti-smuggling Customs Bureau on 24 March 2019; most individuals, including adults and subadults, were in poor health, and their bodies were covered with skin eruptions.).
Malayan Pangolin (e.g., rescue guangdong wildlife rescue center -> Corona: All these Malayan pangolins were rescued by the Guangdong Wildlife Rescue Center, however, 16 died after extensive rescue efforts.).
X21 Dead Malayan Pangolin (e.g., rescued guangdong wildlife rescued center -> Corona: Viral Metagenomics A total of 21 organ samples of lung, lymph and spleen from 11 dead Malayan pangolins that could not be rescued by the Guangdong Wildlife Rescue Center were used to reveal viral diversity of pangolins.).
Work (e.g., supported guangdong natural science foundation -> Corona: ACKNOWLEDGMENTS This work was partially supported by Guangdong Natural Science Foundation grant 2018A030313472, and Guangdong Province Key Laboratory of Microbial Signals and Disease Control grants MSDC-2017-05 and MSDC-2017-06, Guangdong, People s Republic of China., supported natural science foundation guangdong province grant -> Corona: Acknowledgment This work was partially supported by Natural Science Foundation of Guangdong Province Grant 2018A030313472, and Guangdong Province Key Laboratory of Microbial Signals and Disease Control Grant MSDC-2017-05 and MSDC-2017-06, Guangdong, People s Republic of China.).).
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Corona: Virus propagation in LLC-PK cells LLC-PK cells were obtained from Wen's Foodstu?s Group Co, Ltd (Guangdong, China), and cultured in dmem (dulbecco' s modi?ed eagle medium) (hyclone, USA) supplemented with penicillin (100 U/ mL), streptomycin (100 U/mL), and 10% fetal bovine serum (FBS) (BOVOGEN, Australia).
Guangdong isa cultured dmem dulbecco modi ed eagle medium hyclone.
Derived fact.
Guangdong_isa_cultured_dmem_dulbecco_modi_eagle_medium_hycloneCorona: However, SADS-CoV re-emerged in Guangdong on February 2019 and led to the death of around 2000 piglets in one farm (Zhou et al., 2019a).
Guangdong isa lead death 2019 piglet.
Derived fact.
Guangdong_isa_lead_death_2019_pigletCorona: Since the supply of wildlife for consumption in Guangdong mainly comes from yunnan and Guangxi Provinces (Wu et al., 2016b), understanding the presence and dynamic changes in SARS- or SADS- related bat CoVs within and between these provinces is important for predicting and tracing CoVrelated diseases.
Guangdong isa yunnan.
Derived fact.
Guangdong_isa_yunnanCorona: SARS-CoV MERS-CoV Genus Beta-CoVs, Lineage B Beta-CoVs, Lineage C possible natural reservoir bat bat possible Intermediary Host Palm civet Dromedary camel origin guangdong province, China Arabian Peninsula Clinical Epidemiology Total global number reported to WHO More than 8098 people 2254 (from 2012 through 16 September 2018) Affected countries 29 27 Number of deaths 916 800 Mortality More than 10% More than 35% Transmission region Globally Regionally Transmission patterns From animal to human;from human to human The predominant receptor Human angiotensin-convertingenzyme 2 (ACE2) Human dipeptidyl peptidase 4 (DPP4 or CD26) Receptor distribution Arterial and venous endothelium; arterial smooth muscle; small intestine; respiratory tract epithelium; alveolar monocytes and macrophages Respiratory tract epithelium; kidney; small intestine; liver and prostate; activated leukocytes Cell line susceptibility Respiratory tract;kidney; liver Respiratory tract; intestinal tract; genitourinary tract; liver, kidney, neurons; monocyte; Tlymphocyte; and histiocytic cell lines Viral replication efficiency High Higher Ability to inhibit IFN production Delayed recognition andproinflammatory response Delayed recognition and proinflammatory response 3.
Lineage possible natural reservoir bat bat possible isa camel origin guangdong province.
Derived fact.
Lineage_natural_reservoir_bat_isa_camel_origin_guangdong_provinceCorona: In 2003, a novel CoV emerged in the Guangdong province of china that caused a new and deadly outbreak of respiratory disease in humans termed as severe acute respiratory syndrome (SARS-CoV).
Guangdong province china isa caused deadly outbreak respiratory disease.
Derived fact.
Guangdong_province_china_isa_caused_deadly_outbreak_respiratory_diseaseCorona: Bat samples from Mainland china were collected by the guangdong institute of applied biological resources (guangzhou, china) in accordance with guidelines of Regulations for Administration of Laboratory Animals under a license from guangdong Entomological institute Administrative Panel on Laboratory Animal Care. 2.2.
Mainland china isa collected guangdong institute applied biological resource guangzhou.
Derived fact.
Mainland_china_isa_collected_guangdong_institute_applied_biological_resource_guangzhouCorona: This prompted the search for new CoVs in Bat specimens collected in guangdong province between 2013 and 2016.
Bat specimen isa collected guangdong province.
Derived fact.
Bat_specimen_isa_collected_guangdong_provinceCorona: Discussion Since the ?rst report of PEAV in pigs in early February of 2017 in guangdong, China (Gong et al., 2017), this novel swine Enteric cov has been widely detected in guangdong, China, with a prevalence of 43.53% and an emergence in China as early as August 2016 by a retrospective detection study (Zhou et al., 2019).
Enteric cov isa detection guangdong.
Derived fact.
Enteric_cov_isa_detection_guangdongCorona: A retrospective study indicated that the Virus had emerged in guangdong since 53 August 2016 (Zhou et al., 2019).
Virus isa emerged guangdong.
Derived fact.
Virus_isa_emerged_guangdongCorona: The emergence and tracing the animal origin of SarS In late 2002, SarS ?rst emerged in guangdong province in southern China, and rapidly spread to other provinces and other countries, resulting in a global pandemic of severe respiratory diseases (Zhong et al., 2003).
Sar rst isa emerged guangdong province.
Derived fact.
Sar_rst_isa_emerged_guangdong_provinceCorona: SARS is caused by a member of the Betacoronavirus genus and is the first Global pandemic disease that has emerged in the guangdong province of china in 2002.
Global pandemic disease isa emerged guangdong province china.
Derived fact.
Global_pandemic_disease_isa_emerged_guangdong_province_chinaCorona: Air travel facilitated these covs in seeding outbreaks in regions distant from initial localized viral spread: SarS-cov emerged in the guangdong province of southeasternchina in late 2002, and then spread rapidly to other parts of the world, with outbreaks in major cities including Beijing, Hong Kong, Singapore, and Toronto, resulting in one of the first pandemics of the twenty-first century [5].
Sar cov isa emerged guangdong province southeasternchina.
Derived fact.
Sar_cov_isa_emerged_guangdong_province_southeasternchinaCorona: Variable Total N Valid % Gender Female 968 61.5 (n= 1,574) Male 605 38.4 Other 1 0.1 Age Under 18 years 71 4.5 (n=1,582) 18 to 44 years 420 26.5 45 to 64 years 780 49.3 Age 65 or older 311 19.7 province Guang Dong 420 26.5 (n=1,585) Guang Xi 412 26.0 Yun Nan 753 47.5 Residence time < 1 month 4 0.3 (n=1,568) 1 month 1 year 12 0.8 1 year 5 years 26 1.7 > 5 years 1,526 97.3 Family annual <1000 yuan 271 17.3 PCI 1001-10000 yuan 1067 68.2 86 H. Li et al. / Biosafety and Health 1 (2019) 84 90From October 2015 to July 2017, a total of 1,596 residents from eight sites in Yunnan (n=761), Guangxi (n=412), and Guangdong (n=423) provinces were enrolled in this study.
Guangdong n 423 province isa enrolled study.
Derived fact.
Guangdong_423_province_isa_enrolled_studyCorona: Potential infections of h5n1 and h9n2 avian influenza do exist in guangdong populations of china.
Potential infection h5n1 h9n2 avian influenza isa exist guangdong population china.
Derived fact.
Potential_infection_h5n1_h9n2_avian_influenza_isa_exist_guangdong_population_chinaCorona: However, the Reported cov positive samples can only be found in guangdong, Hong Kong, and Macau, possibly due to a lack of investigation in other provinces.
Reported cov positive sample isa find guangdong.
Derived fact.
Reported_cov_positive_sample_isa_find_guangdongCorona: Geographical gradient of SARSr-CoV Among the 45 SARSr-CoV genomes from bats in China, 11 of them were from Hong Kong, 2 were from guangdong, 2 from Guangxi, 5 from Hubei, 20 from Yunnan and one each from Shaanxi, Shanxi, Jilin, Guizhou, Hebei, respectively.
X45 isa guangdong.
Derived fact.
X45_isa_guangdongmed: Cancer health condition is a investigate area southern china yangjiang guangdong province
Cancer health condition isa investigate area southern china yangjiang guangdong province.
Derived factCorona: Slaughtering poultry was positively associated with the outcome only in Guangxi residents, whereas the Association was negative in guangdong residents.
Association isa negative guangdong resident.
Derived fact.
Association_isa_negative_guangdong_residentCorona: This is an interesting phenomenon since the SARS epidemic that emerged in late ACCEPTED MANUSCRIPT AC CE PT ED M AN US CR IP T 2002 was first noticed in guangdong province as an outbreak of acute community-acquired atypical pneumonia syndrome.
X2002 isa noticed guangdong province.
Derived fact.
X2002_isa_noticed_guangdong_provinceCorona: Detection of CoVs in Animals and Discovery of a Novel Species of Merbecovirus from Amur Hedgehogs A total number of 207 alimentary samples, 27 from hedgehogs, 151 from rodents and 29 from Shrews were obtained from various regions of the guangdong province of china and Hong Kong.
Shrew isa obtained region guangdong province china.
Derived fact.
Shrew_isa_obtained_region_guangdong_province_chinaCorona: Furthermore, there are still unanswered questions about SarS, e.g., Why did the first SarS case occur in guangdong province, but all the human-ACE2-using SarSr-CoVs were found in Yunnan province? and Why does R. sinicus in certain areas carry human-ACE2-using SarSr-CoVs but no Figure 2.
Sar case isa occur guangdong province.
Derived fact.
Sar_case_isa_occur_guangdong_provinceCorona: In 2002, a SarS epidemic that originated in guangdong province in China resulted in 916 deaths among more than 8098 patients in 29 countries [11], identifying SarS as the first new infectious disease of the 21st century.
Sar epidemic isa originated guangdong province.
Derived fact.
Sar_epidemic_isa_originated_guangdong_provinceCorona: The SarS pandemic originated in guangdong province in China between 2002 and 2003, and spread to 29 countries, resulting in nearly 8,000 cases and 800 deaths worldwide (Donnelly et al., 2004).
Sar pandemic isa originated guangdong province.
Derived fact.
Sar_pandemic_isa_originated_guangdong_provinceCorona: pigs Four-day-old crossbred conventional newborn piglets produced by Duroc landrace native pigs of guangdong of china were procured from wen' s Foodstu?s Group Co, Ltd (guangdong, china).
Duroc landrace native pig guangdong china isa procured wen.
Derived fact.
Duroc_landrace_native_pig_guangdong_china_isa_procured_wenCorona: The Guangdong wildlife rescue center received 21 live malayan pangolins from the Anti-smuggling Customs Bureau on 24 March 2019; most individuals, including adults and subadults, were in poor health, and their bodies were covered with skin eruptions.
Guangdong wildlife rescue center isa received 21 live malayan pangolin.
Derived fact.
Guangdong_wildlife_rescue_center_isa_received_live_malayan_pangolinCorona: As the original site of the SARS epidemic in humans and SADS outbreak in pigs (Heymann et al., 2013), Guangdong province is also the primary region in china in which wildlife is being consumed.
Guangdong province isa region china.
Derived fact.
Guangdong_province_isa_region_chinaCorona: All these Malayan pangolins were rescued by the guangdong wildlife rescue center, however, 16 died after extensive rescue efforts.
Malayan pangolin isa rescue guangdong wildlife rescue center.
Derived fact.
Malayan_pangolin_isa_rescue_guangdong_wildlife_centerCorona: Viral Metagenomics A total of 21 organ samples of lung, lymph and spleen from 11 dead malayan pangolins that could not be rescued by the guangdong wildlife Rescue center were used to reveal viral diversity of pangolins.
X21 dead malayan pangolin isa rescued guangdong wildlife rescued center.
Derived fact.
X21_dead_malayan_pangolin_isa_rescued_guangdong_wildlife_centerCorona: In 2003, an outbreak of severe acute respiratory syndrome (SARS)-CoV (Betacoronavirus), originating from Guangdong province in China, resulted in 8,096 reported cases and 774 deaths worldwide5.
Guangdong province isa resulted 774.
Derived fact.
Guangdong_province_isa_resulted_774Corona: For betaCoVs, 3 samples from Rhinolophus sinicus captured in Guangdong province contained sarS-related batcovs (sarbecovirus) with 99% nucleotide identity to sarS-related batcov HKU3-12 (GenBank accession no. GQ153547.1) (Table 1).
Guangdong province isa sar relat batcov.
Derived fact.
Guangdong_province_isa_sar_relat_batcovCorona: ACKNOWLEDGMENTS This Work was partially supported by guangdong natural science foundation grant 2018A030313472, and guangdong Province Key Laboratory of Microbial Signals and Disease Control grants MSDC-2017-05 and MSDC-2017-06, guangdong, People s Republic of China.
Work isa supported guangdong natural science foundation.
Derived fact.
Work_isa_supported_guangdong_natural_science_foundationCorona: Acknowledgment This Work was partially supported by natural science foundation of guangdong province grant 2018A030313472, and guangdong province Key Laboratory of Microbial Signals and Disease Control grant MSDC-2017-05 and MSDC-2017-06, guangdong, People s Republic of China.
Work isa supported natural science foundation guangdong province grant.
Derived fact.
Work_isa_supported_natural_science_foundation_guangdong_province_grantCorona2: x21 dead malayan pangolin rescue guangdong wildlife rescue center
21 dead malayan pangolin rescue guangdong wildlife rescue center.
Derived factCorona2: malayan pangolin x21 dead malayan pangolin rescue guangdong wildlife rescue center
Malayan pangolin 21 dead malayan pangolin rescue guangdong wildlife rescue center.
Derived factCorona2: x21 dead malayan pangolin malayan pangolin rescue guangdong wildlife rescue center
21 dead malayan pangolin malayan pangolin rescue guangdong wildlife rescue center.
Derived fact
Alternate guangdong Results
- 21 dead malayan pangolin rescue guangdong wildlife rescue center - Corona2: x21 dead malayan pangolin rescue guangdong wildlife rescue center
- Malayan pangolin 21 dead malayan pangolin rescue guangdong wildlife rescue center - Corona2: Malayan pangolin x21 dead malayan pangolin rescue guangdong wildlife rescue center